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Proteintech
SECISBP2 Polyclonal Antibody, CoraLite® Plus 488
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产品信息
CL488-12798
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SECISBP2 fusion protein Ag3541
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: NPLDSSAPL MKKGKQREIP KAKKPTSLKK IILKERQERK QRLQENAVGP AFTSDDTQDG ESGGDDQFPE QAELSGPEGM DELISTPSVE DKSEEPPGTE LQRDTEASHL APNHTTFPKI HSRRFRDYCS QMLSKEVDAC VTDLLKELVR FQDRMYQKDP VKAKTKRRLV LGLREVLKHL KLKKLKCVII SPNCEKIQSK GGLDDTLHTI IDYACEQNIP FVFALNRKAL GRSLNKAVPV SVVGIFSYDG AQDQFHKMVE LTVAARQAYK TMLENVQQEL VGEPRPQAPP SLPTQGPSCP AEDGPPALKE KEEPHYIEIW KKHLEAYSGC TLELEESLEA STSQMMNLNL
靶标信息
Eukaryotes require a selenocysteine (Sec) insertion sequence (SECIS) element in the 3' untranslated region of the mRNA to decode the UGA codon as Sec. SECIS-binding protein 2 (SBP-2) specifically binds selenoprotein mRNAs to form a functional complex and is essential for the insertion of Sec into selenoproteins. Purified SBP-2 interacts specifically with the SECIS element in the phospholipid hydroperoxide glutathione peroxidase mRNA. SBP-2 shows binding activity in the liver and testis as well as hepatoma cells. SBP-2 binds to a conserved RNA binding domain shared with several ribosomal proteins and eukaryotic translation termination release factor 1. A second domain located N-terminal to the RNA binding domain required for Sec insertion allows SBP-2 to stably associate with the ribosomal fraction of cells. SBP-2 preferentially stimulates incorporation directed by the selenoprotein P and phospholipid hydroperoxide glutathione peroxidase SECIS elements. SBP-2 may have a distinct function in selecting the ribosomes for Sec insertion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11-89K14.1; SECIS-binding protein 2; Selenocysteine insertion sequence-binding protein 2
基因别名: 2210413N07Rik; 2810012K13Rik; SBP2; SECISBP2
UniProt ID: (Human) Q96T21, (Mouse) Q3U1C4, (Rat) Q9QX72
Entrez Gene ID: (Human) 79048, (Mouse) 75420, (Rat) 79049
