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Invitrogen
SEMA6B Polyclonal Antibody
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产品信息
PA5-63581
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DYLNHYPVFV GSGPGRLTPA EGADDLNIQR VLRVNRTLFI GDRDNLYRVE LEPPTSTELR YQRKLTWRSN PSDINVCRMK GKQEGECRNF VKVLL
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.
靶标信息
The SEMA6B gene encodes semaphorin 6B, which belongs to the semaphorin family of proteins known for their roles in guiding axonal development and modulating cellular signaling pathways. Semaphorin 6B primarily functions in the nervous system where it influences axonal guidance, neuronal development, and synapse formation through interactions with neuropilin and plexin receptor complexes. These interactions are crucial during neural development, ensuring proper neuronal wiring and the establishment of functional neural circuits. In addition to its key role in neural connectivity, SEMA6B is increasingly recognized for its involvement in immune responses, where it can modulate the activity and migration of immune cells. In cancer biology, altered expression of SEMA6B has been implicated in tumor progression, affecting tumor cell adhesion and migration, thereby influencing metastasis. Research continues to explore the specific mechanisms of SEMA6B's action and how it can be targeted for therapeutic interventions in neural and cancer-related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; Sema Z; semaphorin VIB; semaphorin Z; Semaphorin-6B; semaphorin-6Ba; Semaphorin-Z
基因别名: SEM-SEMA-Y; SEMA-VIB; SEMA6B; SEMAN; SEMAZ; UNQ1907/PRO4353
UniProt ID: (Human) Q9H3T3
Entrez Gene ID: (Human) 10501
