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Proteintech
SENP1 Polyclonal Antibody
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产品信息
25349-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SENP1 Fusion Protein Ag18028 (1-331 aa encoded by BC045639)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDDIADRMR MDAGEVTLVN HNSVFKTHLL PQTGFPEDQL SLSDQQILSS RQGHLDRSFT CSTRSAAYNP SYYSDNPSSD SFLGSGDLRT FGQSANGQWR NSTPSSSSSL QKSRNSRSLY LETRKTSSGL SNSFAGKSNH HCHVSAYEKS FPIKPVPSPS WSGSCRRSLL SPKKTQRRHV STAEETVQEE EREVYRQLLQ MVTGKQFTIA KPTTHFPLHL SRCLSSSKNT LKDSLFKNGN SCASQIIGSD TSSSGSASIL TNQEQLSHSV YSLSSYTPDV AFGSKDSGTL HHPHHHHSVP HQPDNLAASN TQSEGSDSVI LLKVKDSQTP TP (1-331 aa encoded by BC045639)
靶标信息
SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: SEN1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific protease 1
基因别名: SENP1; SuPr-2
UniProt ID: (Human) Q9P0U3
Entrez Gene ID: (Human) 29843
proteolysis
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of definitive erythrocyte differentiation
protein sumoylation
protein desumoylation
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of transcription from RNA polymerase II promoter
apoptotic signaling pathway
