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Immunogen sequence: SRCLSSSKNT LKDSLFKNGN SCASQIIGSD TSSSGSASIL TNQEQLSHSV YSLSSYTPDV AFGSKDSGTL HHPHHHHSVP HQPDNLAASN TQSEGSDSVI LLKVKDSQTP TPSSTFFQAE LWIKELTSVY DSRARERLRQ IEEQKALALQ LQNQRLQERE HSVHDSVELH LRVPLEKEIP VTVVQETQKK GHKLTDSEDE F; Positive Samples: BxPC-3, HT-29, HepG2, HeLa, Mouse testis, Mouse thymus, Rat testis; Cellular Location: Cytoplasm, Nucleus
SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: SEN1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SUMO-1 protease 2; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; Sumo1/sentrin/SMT3 specific peptidase 1; SuPr-2
基因别名: 2310046A20Rik; D15Ertd528e; E330036L07Rik; SENP1; SuPr-2; Supr2
UniProt ID: (Human) Q9P0U3, (Mouse) P59110
Entrez Gene ID: (Human) 29843, (Mouse) 223870, (Rat) 300193