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Abnova
SESN1 Polyclonal Antibody, MaxPab™
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产品信息
H00027244-B01P
产品规格
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SESN1 (NP_055269.1, 1 a.a. approximately 551 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
See Label
规格
50 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MAEGENEVRW DGLCSRDSTT RETALENIRQ TILRKTEYLR SVKETPHRPS DGLSNTESSD GLNKLLAHLL MLSKRCPFKD VREKSEFILK SIQELGIRIP RPLGQGPSRF IPEKEILQVG SEDAQMHALF ADSFAALGRL DNITLVMVFH PQYLESFLKT QHYLLQMDGP LPLHYRHYIG IMAAARHQCS YLVNLHVNDF LHVGGDPKWL NGLENAPQKL QNLGELNKVL AHRPWLITKE HIEGLLKAEE HSWSLAELVH AVVLLTHYHS LASFTFGCGI SPEIHCDGGH TFRPPSVSNY CICDITNGNH SVDEMPVNSA ENVSVSDSFF EVEALMEKMR QLQECRDEEE ASQEEMASRF EIEKRESMFV FSSDDEEVTP ARAVSRHFED TSYGYKDFSR HGMHVPTFRV QDYCWEDHGY SLVNRLYPDV GQLIDEKFHI AYNLTYNTMA MHKDVDTSML RRAIWNYIHC MFGIRYDDYD YGEINQLLDR SFKVYIKTVV CTPEKVTKRM YDSFWRQFKH SEKVHVNLLL IEARMQAELL YALRAITRYM T
靶标信息
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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