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Proteintech
SETDB1 Polyclonal Antibody
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产品信息
11231-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SETDB1 Fusion Protein Ag1725 (1-350 aa encoded by BC009362)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SETDB1.The calculated molecular weight of SETDB1 is 143 kDa, but the modified SETDB1 protein is about 170 kDa.
Immunogen sequence: MSSLPGCIG LDAATATVES EEIAELQQAV VEELGISMEE LRHFIDEELE KMDCVQQRKK QLAELETWVI QKESEVAHVD QLFDDASRAV TNCESLVKDF YSKLGLQYRD SSSEDESSRP TEIIEIPDED DDVLSIDSGD AGSRTPKDQK LREAMAALRK SAQDVQKFMD AVNKKSSSQD LHKGTLSQMS GELSKDGDLI VSMRILGKKR TKTWHKGTLI AIQTVGPGKK YKVKFDNKGK SLLSGNHIAY DYHPPADKLY VGSRVVAKYK DGNQVWLYAG IVAETPNVKN KLRFLIFFDD GYASYVTQSE LYPICRPLKK TWEDIEDISC RDFIEEYVTA YPNRPMVLLK S (1-350 aa encoded by BC009362)
靶标信息
This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ERG-associated protein with a SET domain, ESET; ERG-associated protein with SET domain; ESET; H3-K9-HMTase 4; Histone H3-K9 methyltransferase 4; Histone-lysine N-methyltransferase SETDB1; histone-lysine N-methyltransferase, H3lysine-9 specific 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1; SET domain ERG-associated histone methyltransferase; SET domain, bifurcated 1; tudor domain containing 21
基因别名: AU022152; ESET; H3-K9-HMTase4; KG1T; KIAA0067; KMT1E; mKIAA0067; SETDB1; TDRD21
UniProt ID: (Human) Q15047
Entrez Gene ID: (Human) 9869, (Mouse) 84505, (Rat) 689883
transcription, DNA-templated
Ras protein signal transduction
response to vitamin
histone lysine methylation
response to ethanol
positive regulation of methylation-dependent chromatin silencing
negative regulation of transcription from RNA polymerase II promoter
inner cell mass cell proliferation
regulation of transcription, DNA-templated
chromatin modification
methylation
histone H3-K9 trimethylation
bone development
