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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SFRP1 Antibodies

          Invitrogen

          SFRP1 Polyclonal Antibody

          查看其他15个SFRP1抗体
          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
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          Cite SFRP1 Polyclonal Antibody

          • 抗体检测数据 (3)
          SFRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          SFRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 3

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          SFRP1 Antibody (PA5-118796) in IHC (P)

          Immunohistochemical analysis of SFRP1 in Mouse kidney tissue using a SFRP1 polyclonal antibody (Product # PA5-118796). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          查看产品

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          SFRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SFRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SFRP1 Antibody in Western Blot (WB)

          产品信息

          PA5-118796

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000-1:3,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50-1:200
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          A synthesized peptide derived from human SFRP1(Accession Q8N474), corresponding to amino acid residues S195-K245.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.4, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2903296

          产品详细信息

          Antibody detects endogenous levels of total SFRP1.

          靶标信息

          Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP1 is expressed in several human tissues, with the highest levels in heart.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: frizzled-related protein; FRP-1; SARP-2; Secreted apoptosis-related protein 2; Secreted frizzled-related protein 1; secreted frizzled-related sequence protein 1; sFRP-1

          查看更多 收起

          基因别名: 2210415K03Rik; AW011917; AW107218; AW742929; FRP; FRP-1; FRP1; FrzA; SARP2; sFRP-1; SFRP1

          查看更多 收起

          UniProt ID: (Human) Q8N474, (Mouse) Q8C4U3

          查看更多 收起

          Entrez Gene ID: (Human) 6422, (Mouse) 20377, (Rat) 84402

          查看更多 收起

          功能
          cysteine-type endopeptidase activity G-protein coupled receptor activity frizzled binding protein binding drug binding heparin binding Wnt-protein binding identical protein binding Wnt-activated receptor activity molecular_function transmembrane signal receptor
          参与通路
          osteoblast differentiation ureteric bud development positive regulation of cell-matrix adhesion hematopoietic progenitor cell differentiation proteolysis G-protein coupled receptor signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation male gonad development female gonad development cellular response to starvation dorsal/ventral axis specification regulation of cell cycle process negative regulation of gene expression negative regulation of epithelial to mesenchymal transition neural crest cell fate commitment response to organic cyclic compound menstrual cycle phase positive regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of ossification positive regulation of cell growth negative regulation of cell growth negative regulation of cell migration negative regulation of BMP signaling pathway negative regulation of osteoblast proliferation somatic stem cell population maintenance response to drug positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of JUN kinase activity positive regulation of GTPase activity cellular response to fibroblast growth factor stimulus stromal-epithelial cell signaling involved in prostate gland development negative regulation of B cell differentiation positive regulation of fat cell differentiation negative regulation of osteoblast differentiation negative regulation of osteoclast differentiation regulation of angiogenesis positive regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of insulin secretion negative regulation of bone remodeling negative regulation of fibroblast proliferation digestive tract morphogenesis positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of peptidyl-tyrosine phosphorylation positive regulation of stress fiber assembly positive regulation of focal adhesion assembly canonical Wnt signaling pathway hematopoietic stem cell differentiation bone trabecula formation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of branching involved in prostate gland morphogenesis negative regulation of androgen receptor signaling pathway cellular response to vitamin D cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus cellular response to prostaglandin E stimulus cellular response to estrogen stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to X-ray cellular response to heparin dopaminergic neuron differentiation cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure Wnt signaling pathway involved in somitogenesis convergent extension involved in somitogenesis positive regulation of canonical Wnt signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of dopaminergic neuron differentiation midbrain morphogenesis negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of non-canonical Wnt signaling pathway negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation negative regulation of fibroblast apoptotic process positive regulation of fibroblast apoptotic process somitogenesis neural tube closure multicellular organism development anterior/posterior pattern specification Wnt signaling pathway neural tube development actin cytoskeleton organization hemopoiesis cell differentiation regulation of ossification substrate adhesion-dependent cell spreading development of primary male sexual characteristics Wnt signaling pathway, planar cell polarity pathway regulation of establishment of planar polarity positive regulation of extrinsic apoptotic signaling pathway non-canonical Wnt signaling pathway
          It has to be done as per old AB suggested Products section.
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