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Invitrogen
SFXN4 Polyclonal Antibody
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产品信息
PA5-69967
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the N terminal region of human SFXN4
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This target displays homology in the following species: Human: 100%
靶标信息
Sideroflexin 4 (SFXN4) is a gene primarily associated with mitochondrial functionality and disease. It encodes a protein that is crucial for the assembly of complex I within mitochondria, a critical component of the electron transport chain. Mutations in SFXN4 can result in mitochondrial diseases due to its pivotal role in this process. Interestingly, SFXN4 belongs to the sideroflexin family, traditionally known for amino acid transport, indicating a functional evolution to support mitochondrial assembly. In the context of cancer, specifically ovarian cancer, SFXN4 is involved in the synthesis of iron-sulfur clusters (Fe-S), which are essential for cell growth and division. Inhibition of SFXN4 disrupts Fe-S biogenesis, highlighting its potential as a target for anti-cancer therapy. Additionally, SFXN4's expression and function have been correlated with immune pathways in hepatocellular carcinoma, suggesting broader implications in cancer biology. Knockdown studies and natural mutations demonstrate SFXN4's role in mitochondrial diseases, including macrocytic anemia observed in zebrafish models and implications in human mitochondriopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Breast cancer resistance marker 1; Sideroflexin-4
基因别名: BCRM1; COXPD18; SFXN4
UniProt ID: (Human) Q6P4A7
Entrez Gene ID: (Human) 119559
