Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 3
SGPP2 Antibody (PA5-42767) in WB
Western blot analysis was performed on whole cell extracts of MKN45 (Lane 1), SK-OV-3 (Lane 2), A-431 (Lane 3), THP-1 (Lane 4), COS-7 (Lane 5) and A549 (Lane 6). The blot was probed with Anti-SGPP2 Polyclonal Antibody (Product # PA5-42767, 2 µg/ml) and detected by chemiluminescence using Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/ml, 1:4000 dilution). A 35 kDa band corresponding to SGPP2 was observed across the cell lines tested.
Product Details
PA5-42767
产品规格
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human SGPP2
Conjugate
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2606827
Product Specific Information
Peptide sequence: SKPAESLPVI QNIPPLTTYM LVLGLTKFAV GIVLILLVRQ LVQNLSLQVL
Sequence homology: Cow: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 85%
Target Information
Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/Gprotein- coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family whichplay a role in attenuating intracellular S1P signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Bioinformatics
Protein Aliases: FLJ39004; sphingosine 1-phosphate phosphohydrolase 2; Sphingosine-1-phosphatase 2; Sphingosine-1-phosphate phosphatase 2; sphingosine-1-phosphate phosphotase 2; SPPase2
Gene Aliases: SGPP2; SPP2; SPPase2
UniProt ID: (Human) Q8IWX5
Entrez Gene ID: (Human) 130367
Molecular Function:
phosphatase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support