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Invitrogen
SHOX Polyclonal Antibody
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SHOX Antibody (PA5-120677) in WB
Western blot analysis of SHOX in extracts of various cell lines. Samples were incubated with SHOX Polyclonal antibody (Product # PA5-120677) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-120677
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment).
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: 293T, BxPC-3, Mouse brain, Rat heart. The target is usually found in the following locations: Nucleus.
Immunogen sequence: NGGGGGGGGK KDSITYREVL ESGLARSREL GTSDSSLQDI TEGGGHCPVH LFKDHVDNDK EKLKEFGTAR VAEGIYECKE KREDVKSEDE D
靶标信息
Homeodomain proteins (HP) are transcriptional regulators that coordinate the expression of genes involved in development, differentiation and cellular transformation. HPs are characterized by a conserved domain of 60 amino acid residues that recognize and bind a site in the regulatory region of the target gene. SHOX, a member of the bicoid subfamily of the paired homeobox family, controls fundamental aspects of growth and development and undergoes splicing resulting in two isoforms, SHOXA and SHOXB. SHOXA is expressed in skeletal muscle, placental, pancreas, heart and bone marrow fibroblast and, to a lesser extent, in kidney and lung. SHOXB is highly expressed in osteogenic cells, but not expressed in brain, kidney, liver or lung. Defects in the gene SHOXX cause Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: growth control factor, X-linked; Pseudoautosomal homeobox-containing osteogenic protein; Short stature homeobox protein; Short stature homeobox-containing protein
基因别名: GCFX; PHOG; SHOX; SHOXY; SS
UniProt ID: (Human) O15266
Entrez Gene ID: (Human) 6473
