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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SIAH1 Antibodies

          Invitrogen

          SIAH1 Polyclonal Antibody

          View all (11) SIAH1 antibodies
          Datasheet
          Protocols
          Tech Support

          Cite SIAH1 Polyclonal Antibody

          Datasheet
          Protocols
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          • Antibody Testing Data (1)
          SIAH1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          SIAH1 Antibody (PA5-17998) in WB

          Western Blot staining of Human Liver lysate using Product # PA5-17998 at a concentration of 0.1 µg/mL, the primary antibody incubation was 1 hour and the detection method was chemiluminescence. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-17998

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          1-3 µg/mL
          -
          产品规格

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Goat / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          Synthetic peptide sequence (SRQTATALPTGTSKC) corresponding to the N-terminus amino acids of SIAH1

          Conjugate

          Unconjugated

          形式

          Liquid

          浓度

          0.5 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          TBS, pH 7.3, with 0.5% BSA

          内含物

          0.02% sodium azide

          保存条件

          -20° C, Avoid Freeze/Thaw Cycles

          RRID

          AB_10985773

          Product Specific Information

          This product is expected to recognize both reported isoforms (NP_003022.3; NP_001006611.1).

          This antibody is predicted to react with bovine and canine based on sequence homology.

          Target Information

          This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase SIAH1A; E3 ubiquitin-protein ligase SIAH1B; FLJ08065; h HUMSIAH; hSIAH1; mSiah-1a; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH1A; RING-type E3 ubiquitin transferase SIAH1B; seven in absentia 1A; Seven in absentia homolog 1; Seven in absentia homolog 1a; Seven in absentia homolog 1b; Siah-1; Siah-1a; Siah-1b

          View more View less

          Gene Aliases: AA960570; AA982064; AI853500; HUMSIAH; SIAH; siah-1b; SIAH1; SIAH1A; Siah1b; Sinh1a; Sinh1b

          View more View less

          UniProt ID: (Human) Q8IUQ4, (Rat) Q920M9, (Mouse) P61092, (Mouse) Q06985

          View more View less

          Entrez Gene ID: (Human) 6477, (Rat) 140941, (Mouse) 20437, (Mouse) 20438

          View more View less

          Molecular Function: ubiquitin-protein ligase protein modifying enzyme

          Function(s)
          protein polyubiquitination ubiquitin-dependent protein catabolic process apoptotic process cell cycle spermatogenesis nervous system development axon guidance anatomical structure morphogenesis protein catabolic process protein destabilization protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process cellular protein metabolic process neuron apoptotic process positive regulation of intrinsic apoptotic signaling pathway male meiosis I multicellular organism development post-embryonic development cell differentiation regulation of multicellular organism growth protein ubiquitination
          Process(es)
          ubiquitin-protein transferase activity protein binding protein C-terminus binding zinc ion binding ligase activity identical protein binding ubiquitin protein ligase activity protein homodimerization activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
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          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

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