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Invitrogen
SIAH2 Monoclonal Antibody (24E6H3)
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产品信息
MA5-24780
应用
建议稀释比
已发表文章
产品规格
种属反应
Fruit fly,
Human,
Mouse,
Pig
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
24E6H3
抗原
Synthetic peptide made to an N-terminal portion of the drosophila SINA protein (within residues 1-100).
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
tissue culture supernatant
内含物
0.1% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This is specific for human SIAH2 and Drosophila SINA in proliferating cells and stem cells. This does not detect Drosophila SINAH or normal, nondividing cells.
靶标信息
SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: anon-fast-evolving-2H7; CG9949-PA; CG9949-PB; CG9949-PC; E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase sina; EC 6.3.2; HL08111p; mSiah2; RING-type E3 ubiquitin transferase SIAH2; RING-type E3 ubiquitin transferase sina; seven in absenti; Seven in absentia homolog 2; Seven in absentia protein; seven-in-absentia; Siah-2; sina-PA; sina-PB; sina-PC
基因别名: AA415433; anon-EST:fe2H7; CG9949; Dmel\CG9949; Dmel_CG9949; hSiah2; sia; SIAH2; SINA; Sinh2
UniProt ID: (Human) O43255, (Mouse) Q06986, (Fruit fly) P21461
Entrez Gene ID: (Human) 6478, (Pig) 100622531, (Mouse) 20439, (Fruit fly) 39884
transcription corepressor activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
ubiquitin conjugating enzyme binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein modifying enzyme
protein polyubiquitination
ubiquitin-dependent protein catabolic process
apoptotic process
cell cycle
small GTPase mediated signal transduction
axon guidance
regulation of protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular protein catabolic process
cellular protein metabolic process
negative regulation of canonical Wnt signaling pathway
negative regulation of nucleic acid-templated transcription
negative regulation of extrinsic apoptotic signaling pathway
multicellular organism development
protein ubiquitination
sensory organ development
R7 cell fate commitment
proteasomal protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
enteroendocrine cell differentiation
sevenless signaling pathway
regulation of R7 cell differentiation
