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Invitrogen
SIPA1L1 Polyclonal Antibody
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产品信息
PA5-51761
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: IRQRSNSDIT ISELDVDSFD ECISPTYKTG PSLHREYGST SSIDKQGTSG ESFFDLLKGY KDDKSDRGPT PTKLSDFLIT GGGKGSGFSL DVIDGPISQR ENLRLFKERE KPLKRRSKSE TGDSSIFRKL RNAKGEELGK SSDLEDNRSE
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.
靶标信息
Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E6-targeted protein 1; H_DJ1140G11.1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1 like 1; Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; WUGSC:H_DJ1140G11.1
基因别名: E6TP1; KIAA0440; SIPA1L1
UniProt ID: (Human) O43166
Entrez Gene ID: (Human) 26037
biological_process
actin cytoskeleton reorganization
regulation of GTPase activity
ephrin receptor signaling pathway
regulation of synaptic plasticity
regulation of axonogenesis
regulation of small GTPase mediated signal transduction
regulation of dendritic spine morphogenesis
activation of GTPase activity
