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Proteintech
SIRT7 Polyclonal Antibody
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产品信息
12994-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SIRT7 Fusion Protein Ag3656 (1-400 aa encoded by BC017305)
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAAGGLSRS ERKAAERVRR LREEQQRERL RQVSRILRKA AAERSAEEGR LLAESADLVT ELQGRSRRRE GLKRRQEEVC DDPEELRGKV RELASAVRNA KYLVVYTGAG ISTAASIPDY RGPNGVWTLL QKGRSVSAAD LSEAEPTLTH MSITRLHEQK LVQHVVSQNC DGLHLRSGLP RTAISELHGN MYIEVCTSCV PNREYVRVFD VTERTALHRH QTGRTCHKCG TQLRDTIVHF GERGTLGQPL NWEAATEAAS RADTILCLGS SLKVLKKYPR LWCMTKPPSR RPKLYIVNLQ WTPKDDWAAL KLHGKCDDVM RLLMAELGLE IPAYSRWQDP IFSLATPLRA GEEGSHSRKS LCRSREEAPP GDRGAPLSSA PILGGWFGRG CTKRTKRKKV T (1-400 aa encoded by BC017305)
靶标信息
SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT7 is included in class IV. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT7 is included in class IV of the sirtuin family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: MGC126840; MGC126842; NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; Regulatory protein SIR2 homolog 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; SIR2-like protein 7; sir2-related protein type 7; sirtuin type 7
基因别名: SIR2L7; SIRT7
UniProt ID: (Human) Q9NRC8, (Mouse) Q8BKJ9, (Rat) B2RZ55
Entrez Gene ID: (Human) 51547, (Mouse) 209011, (Rat) 303745
chromatin binding
protein binding
metal ion binding
NAD+ binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
histone deacetylase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
N-acetylgalactosamine-6-phosphate deacetylase activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
molecular_function
negative regulation of transcription from RNA polymerase II promoter
positive regulation of transcription involved in exit from mitosis
rRNA transcription
histone H3 deacetylation
histone H4 deacetylation
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
biological_process
