Invitrogen

SIX1 Polyclonal Antibody

查看其他7个SIX1抗体

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SIX1 Antibody in Western Blot (WB) — Western blot analysis of SIX1 in MCF-7 whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Samples were incubated with SIX1 polyclonal antibody (Product # PA5-95341) using a 0.5 µg/mL dilution. developed was performed using enhanced chemiluminescence (ECL).

产品细节

Applications

Tested Dilution

Publications

免疫印迹 (WB)

0.1-0.5 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence at the C-terminus of human SIX1, different from the related mouse sequence by one amino acid.

偶联物

Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2807144

产品详细信息

Synthetic peptide sequence: 245-282aa, NYSLPGLTASQPSHGLQTHQHQLQDSLLGPLTSSLVDL.

Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

靶标信息

The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Homeobox protein SIX1; Sine oculis homeobox homolog 1

基因别名: BOS3; DFNA23; SIX1; TIP39

UniProt ID: (Human) Q15475

Entrez Gene ID: (Human) 6495

分子生物学功能: homeodomain transcription factor

negative regulation of transcription from RNA polymerase II promoter ureteric bud development branching involved in ureteric bud morphogenesis organ induction kidney development outflow tract morphogenesis regulation of transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process pattern specification process skeletal muscle tissue development sensory perception of sound cell proliferation regulation of synaptic growth at neuromuscular junction regulation of skeletal muscle satellite cell proliferation facial nerve morphogenesis epithelial cell differentiation thyroid gland development olfactory placode formation regulation of protein localization protein localization to nucleus aorta morphogenesis inner ear morphogenesis middle ear morphogenesis negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thymus development neuron fate specification generation of neurons embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis inner ear development regulation of epithelial cell proliferation myoblast migration pharyngeal system development myotome development fungiform papilla morphogenesis trigeminal ganglion development otic vesicle development metanephric mesenchyme development regulation of branch elongation involved in ureteric bud branching positive regulation of ureteric bud formation mesonephric tubule formation ureter smooth muscle cell differentiation positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis positive regulation of branching involved in ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis positive regulation of mesenchymal cell proliferation involved in ureter development regulation of skeletal muscle cell differentiation

参与通路

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding transcription regulatory region DNA binding