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Invitrogen
SKI Polyclonal Antibody
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产品信息
PA5-66852
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human SKI
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: SFYSYKSFETA VAPNVALAPP AQQKVVSSPP CAAAVSRAPE PLATCTQPRK RKLTVDTPGA PETLAPVAAP EEDKDSEAEV EVESRE
Highest antigen sequence identity to the following orthologs - mouse 85%, rat 85%.
靶标信息
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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