This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 86%
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.
蛋白别名: hNaDC3; Na(+)-coupled carboxylate transporter 3; Na(+)/dicarboxylate cotransporter 3; NaC3; NaDC-3; SLC13A3; sodium-dependent high affinity dicarboxylate transporter 3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3
基因别名: NADC3; SDCT2; SLC13A3
UniProt ID: (Human) Q5JYD0
Entrez Gene ID: (Human) 64849