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Proteintech
SLC22A18 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
11646-2-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SLC22A18 Fusion Protein Ag2245 (17-424 aa encoded by BC015571)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
规格
45 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MSALGRSSV ILLTYVLAAT ELTCLFMQFS IVPYLSRKLG LDSIAFGYLQ TTFGVLQLLG GPVFGRFADQ RGARAALTLS FLAALALYLL LAAASSPALP GVYLLFASRL PGALMHTLPA AQMVITDLSA PEERPAALGR LGLCFGVGVI LGSLLGGTLV SAYGIQCPAI LAALATLLGA VLSFTCIPAS TKGAKTDAQA PLPGGPRASV FDLKAIASLL RLPDVPRIFL VKVASNCPTG LFMVMFSIIS MDFFQLEAAQ AGYLMSFFGL LQMVTQGLVI GQLSSHFSEE VLLRASVLVF IVVGLAMAWM SSVFHFCLLV PGLVFSLCTL NVVTDSMLIK AVSTSDTGTM LGLCASVQPL LRTLGPTVGG LLYRSFGVPV FGHVQVAINT LVLLVLWRKP MPQRKDKVR (17-424 aa encoded by BC015571)
靶标信息
ORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein that localizes at the apical membrane surface of renal proximal tubules. ORCTL2 is expressed at high levels in the kidney, liver, colon and in fetal renal proximal tubules and present at lower levels in heart, brain and lung. Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations based on a proton efflux antiport mechanism and may also play a role in the transport of chloroquine and quinidine-related compounds in kidney. Defects in ORCTL2 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: imprinted multi-membrane spanning polyspecific transporter-related protein 1; Imprinted multi-membrane-spanning polyspecific transporter-related protein 1; Multi-membrane-spanning polyspecific transporter; ORCTL-2; Organic cation transporter-like protein 2; organic cationic transporter-like 2; solute carrier family 22 (organic cation transporter), member 18; Solute carrier family 22 member 18; tumor suppressing subtransferable candidate 5
基因别名: AW260131; BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2; p45-BWR1A; Slc22a18; Slc22a1l; Slc67a1; TSSC5
UniProt ID: (Mouse) Q78KK3, (Rat) Q6AY78
Entrez Gene ID: (Mouse) 18400, (Rat) 309131
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