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Invitrogen
SLC39A4 Polyclonal Antibody
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产品信息
PA5-21069
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 15 amino acid peptide near the center of human ZIP4.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Wet ice
产品详细信息
A suggested positive control is mouse small intestine tissue lysate.
PA5-21069 can be used with blocking peptide PEP-1183.
靶标信息
The zinc transporter ZIP4, also known as SLC39A4, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP4 was initially identified as zinc-uptake transporter in the intestine and as a candidate gene for acrodermatitis enteropathica (AE), a rare inherited defect in the absorption of dietary zinc. Similar to other ZIP family members, aberrant expression of ZIP4 has been linked to cancer, specifically the progression and aggressiveness of pancreatic cancer. ZIP4 expression has also been shown to be activated in hepatocellular carcinomas, acting to repress apoptosis, enhance cell cycle and increase migration, suggesting ZIP4 may play a role in multiple types of cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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