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Invitrogen
SLC4A8 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-139959
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.4 mg/mL
规格
40 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: ELEGHRTLYV GVRMPLGRQS HRHHRTHGQK HRRRGRGKGA SQGEEGLEAL AHDTPSQRV
Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 97%.
靶标信息
Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: electroneutral Na(+)-driven Cl-HCO3 exchanger; k-NBC3; NDCBE; NDCBE1; solute carrier family 4, sodium bicarbonate cotransporter, member 8; unnamed protein product
基因别名: NBC3; NDCBE
UniProt ID: (Human) Q2Y0W8
Entrez Gene ID: (Human) 9498
inorganic anion exchanger activity
zinc ion binding
anion transmembrane transporter activity
sodium:bicarbonate symporter activity
sodium ion transmembrane transporter activity
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
identical protein binding
sodium,bicarbonate:chloride antiporter activity
anion transport
bicarbonate transport
sodium ion transmembrane transport
regulation of membrane potential
modulation of synaptic transmission
regulation of intracellular pH
transmembrane transport
basolateral protein secretion
transport across blood-brain barrier
chloride transmembrane transport
regulation of synaptic vesicle exocytosis
positive regulation of synaptic vesicle exocytosis
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
