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SLC8A1 Antibody (PA5-104159) in IHC (P)
Immunohistochemistry analysis of SLC8A1 in rat heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SLC8A1 polyclonal antibody (Product # PA5-104159) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-104159
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SLC8A1(Accession P32418), corresponding to amino acid residues Y261-E311.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853487
产品详细信息
Antibody detects endogenous levels of total SLC8A1.
靶标信息
Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Na-Ca exchanger; Na/Ca exchanger; Sodium/calcium exchanger 1; sodium/calcium exchanger isoform NaCa7; solute carrier family 8 (sodium/calcium exchanger), member 1; Solute carrier family 8 member 1; solute carrier family 8, member 1
基因别名: AI852629; AV344025; CNC; D930008O12Rik; Ncx; NCX1; SLC8A1
UniProt ID: (Human) P32418, (Mouse) P70414, (Rat) Q01728
Entrez Gene ID: (Human) 6546, (Mouse) 20541, (Rat) 29715
calcium:sodium antiporter activity
calcium ion binding
protein binding
calmodulin binding
cytoskeletal protein binding
ankyrin binding
ion channel binding
antiporter activity
metal ion binding
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
secondary carrier transporter
regulation of the force of heart contraction
regulation of heart rate
regulation of sodium ion transport
ion transport
cellular sodium ion homeostasis
muscle contraction
response to nutrient
response to glucose
regulation of cell communication by electrical coupling
positive regulation of fibroblast migration
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
vascular smooth muscle contraction
telencephalon development
positive regulation of bone mineralization
response to ATP
cellular response to reactive oxygen species
sodium ion transmembrane transport
response to immobilization stress
response to muscle stretch
response to drug
response to hydrogen peroxide
relaxation of smooth muscle
negative regulation of cytosolic calcium ion concentration
cardiac muscle cell development
calcium ion homeostasis
relaxation of cardiac muscle
cardiac muscle contraction
cytosolic calcium ion transport
calcium ion transport into cytosol
calcium ion import
calcium ion transmembrane transport
cellular response to caffeine
cellular response to cAMP
sodium ion export
cellular response to hypoxia
membrane depolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
sodium ion import
positive regulation of the force of heart contraction
calcium ion export
regulation of cardiac conduction
response to hypoxia
embryonic placenta development
heart morphogenesis
transport
sodium ion transport
calcium ion transport
cellular calcium ion homeostasis
cell communication
positive regulation of cytosolic calcium ion concentration
post-embryonic development
embryonic heart tube development
muscle fiber development
regulation of calcium ion transport
transmembrane transport
regulation of cardiac muscle cell membrane potential
