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Proteintech

SLIT2 Polyclonal Antibody

23 篇参考文献
查看其他12个SLIT2抗体

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产品信息

20217-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
查看14篇已发表文章 14篇已发表文章

免疫组化 (IHC)

-
查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:500
查看4篇已发表文章 4篇已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.19 mg/mL

规格

28.5 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

The antibody is specific to SLIT2.

靶标信息

SLIT2 are ligands for Robo receptors and play a vital role for axonal migration/navigation during neural development. A number of cleavage products through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and adult spinal cord.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: downregulated during adipocyte differentiation-1; Drosophila slit protein homolog; leucine-rich repeat EGF-like repeat secreted protein; neurogenic extracellular slit protein; secreted ligand for robo receptors; slit-2; unnamed protein product

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基因别名: b2b1200.1Clo; Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; SLIL3; Slit-2

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UniProt ID: (Human) O94813, (Mouse) Q9R1B9

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Entrez Gene ID: (Human) 9353, (Mouse) 20563, (Rat) 360272

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功能
GTPase inhibitor activity calcium ion binding protein binding heparin binding identical protein binding protein homodimerization activity laminin-1 binding proteoglycan binding chemorepellent activity Roundabout binding receptor binding extracellular matrix structural constituent heparan sulfate proteoglycan binding follicle-stimulating hormone receptor activity
参与通路
metanephros development ureteric bud development in utero embryonic development kidney development negative regulation of protein phosphorylation cell migration involved in sprouting angiogenesis negative regulation of leukocyte chemotaxis aortic valve morphogenesis pulmonary valve morphogenesis signal transduction axonogenesis axon guidance motor neuron axon guidance negative regulation of cell proliferation negative regulation of lamellipodium assembly negative regulation of endothelial cell migration negative regulation of gene expression negative regulation of neuron projection development negative regulation of smooth muscle cell migration olfactory bulb development chemorepulsion involved in postnatal olfactory bulb interneuron migration corticospinal neuron axon guidance through spinal cord telencephalon cell migration negative regulation of cell growth negative regulation of cell migration negative regulation of axon extension negative regulation of actin filament polymerization retinal ganglion cell axon guidance regulation of cellular component size cellular response to hormone stimulus dorsal/ventral axon guidance Roundabout signaling pathway positive regulation of apoptotic process negative regulation of vascular permeability branching morphogenesis of an epithelial tube neuron projection morphogenesis axon extension involved in axon guidance regulation of neurogenesis regulation of axonogenesis negative chemotaxis induction of negative chemotaxis negative regulation of small GTPase mediated signal transduction response to cortisol positive regulation of synapse assembly synapse maturation ventricular septum morphogenesis developmental growth involved in morphogenesis epithelial tube morphogenesis mammary gland duct morphogenesis mammary duct terminal end bud growth apoptotic process involved in luteolysis negative regulation of chemokine-mediated signaling pathway cellular response to heparin negative regulation of smooth muscle cell chemotaxis negative regulation of mononuclear cell migration negative regulation of neutrophil chemotaxis negative regulation of monocyte chemotaxis negative regulation of retinal ganglion cell axon guidance negative regulation of cellular response to growth factor stimulus cell-cell adhesion neuron projection extension G-protein coupled receptor signaling pathway spinal cord development chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration response to nutrient levels cellular response to platelet-derived growth factor stimulus follicle-stimulating hormone signaling pathway cellular response to hypoxia positive regulation of axonogenesis circulatory system development
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