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Invitrogen
SMARCC2 Recombinant Rabbit Monoclonal Antibody (PSH12-00)
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SMARCC2 Antibody (MA569984) in ICC/IF
Immunocytochemistry analysis of SMARCC2 in Neuro-2a cells. Samples were incubated with SMARCC2 monoclonal antibody (Product # MA569984) using a dilution of 1:500 in 1% BSA in PBST overnight at 4°C followed by Goat Anti-Rabbit IgG H&L (iFluor™ 594) at a dilution of 1:1,000. Cells were fixed in 4% paraformaldehyde for 15 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 15 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. PBS instead of the primary anti... View More
产品信息
MA569984
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH12-00
抗原
Recombinant protein within human BAF170 aa 915-1,214.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive control: K-562 cell lysate, A431 cell lysate, MCF7 cell lysate, HeLa cell lysate, SW620 cell lysate, SW680 cell lysate, PANC cell lysate, C2C12 cell lysate, NIH/3T3 cell lysate, Neuro-2a cell lysate, PC-12 cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, human brain tissue, human stomach tissue, mouse stomach tissue, rat stomach tissue.
Subcellular location: Nucleus.
靶标信息
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAF170; BRG1-associated factor 170; chromatin remodeling complex BAF170 subunit; DKFZp313D0632; mammalian chromatin remodeling complex BRG1-associated factor 170; similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c2; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI3-like protein
基因别名: 5930405J04Rik; BAF170; CRACC2; Rsc8; SMARCC2
UniProt ID: (Human) Q8TAQ2, (Mouse) Q6PDG5
Entrez Gene ID: (Rat) 685179, (Human) 6601, (Mouse) 68094
negative regulation of transcription from RNA polymerase II promoter
nucleosome disassembly
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
ATP-dependent chromatin remodeling
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
transcription, DNA-templated
covalent chromatin modification
regulation of transcription, DNA-templated
nervous system development
chromatin modification
