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Immunogen sequence: DLKLWEIGK IIGGMWRDLT DEEKQEYLNE YEAEKIEYNE SMKAYHNSPA YLAYINAKSR AEAALEEESR QRQSRMEKGE PYMSIQPAED PDDYDDGFSM KHTATARFQR NHRLISEILS ESVVPDVRSV VTTARMQVLK RQVQSLMVHQ RKLEAELLQI EERHQEKKRK FLESTDSFNN ELKRLCGLKV EVDMEKIAAE IAQAEEQARK RQEEREKEAA EQAERSQSSI VPEEEQAANK GEEKKDDENI PMETEETHLE ETTESQQNGE EGTSTPEDKE SGQEGVDSMA EEGTSDSNTG SESNSATVEE PPTDPIPEDE KKE (90-411 aa encoded by BC007082)
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; SMARCE 1; SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
基因别名: 2810417B20Rik; 5830412H02Rik; 9030408N19Rik; Baf27; BAF57; CSS5; RGD1304726; SMARCE1
UniProt ID: (Human) Q969G3, (Rat) Q56A18, (Mouse) O54941
Entrez Gene ID: (Human) 6605, (Rat) 303518, (Mouse) 57376
分子生物学功能: chromatin/chromatin-binding, or -regulatory protein