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Invitrogen
SMOC1 Recombinant Rabbit Monoclonal Antibody (PSH07-84)
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SMOC1 Antibody (MA5-55599) in WB
Western blot was performed using SMOC1 Recombinant Rabbit Monoclonal Antibody (PSH07-84) (Product # MA5-55599) and a 55 kDa band corresponding to SMOC1 was observed in conditioned medium of Hela serum starved for 48 hours. 7 µl of conditioned media of HeLa (Lane 1) and HeLa treated with serum starvation (48 hours) (Lane 2) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # I... View More
产品信息
MA5-55599
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH07-84
抗原
Recombinant protein within human smoc1 aa 1-434.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS/PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Positive Control: HeLa cell lysate.
Tissue Specificity: Widely expressed in many tissues with a strongest signal in ovary. No expression in spleen.
Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane.
Sequence Similarities: No Cross with Mouse/Rat.
Predicted band size: 223 kDa.
靶标信息
Secreted modular calcium-binding protein 1 (SMOC1) is a gene located on chromosome 14q24.2, encoding a member of the SPARC (Secreted Protein, Acidic, and Rich in Cysteine) family of matricellular proteins. SMOC1 is characterized by its multiple domains that facilitate calcium binding and interaction with various components of the extracellular matrix. This protein plays a crucial role in modulating cell-matrix interactions and signaling pathways involved in cellular adhesion, migration, and differentiation. SMOC1 is expressed in multiple tissues, including the eyes, limbs, and the central nervous system, and is essential for developmental processes such as angiogenesis and tissue formation. Mutations in SMOC1 have been linked to ocular conditions like anterior segment dysgenesis and microphthalmia, reflecting its significance in eye development. Current studies focus on the protein's broader implications in developmental disorders and its potential as a therapeutic target in diseases associated with extracellular matrix dysregulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Secreted modular calcium-binding protein 1; SMOC-1; SPARC-related modular calcium-binding protein 1
基因别名: OAS; SMOC1
UniProt ID: (Human) Q9H4F8
Entrez Gene ID: (Human) 64093
