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Immunogen sequence: LAQLITQAKH TAKSISDQCA ESPAGHSFLS WLGFSSMDTN GSYTANDLDE MGQDSVRKTD EYLEKALEYL RQIFRLSEAQ LRQFTLALGT TQDENGKKQL PDCI
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 84%.
The protein encoded by SMPD4 is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Neutral sphingomyelinase 3; Neutral sphingomyelinase III; neutral sphingomyelinase-3; nSMase-3; SKNY protein; Sphingomyelin phosphodiesterase 4; sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
基因别名: KIAA1418; NET13; NSMASE-3; NSMASE3; SKNY; SMPD4
UniProt ID: (Human) Q9NXE4
Entrez Gene ID: (Human) 55627
分子生物学功能:
hydrolase
phosphodiesterase
metabolite interconversion enzyme
