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Proteintech
SNCB Polyclonal Antibody
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产品信息
10498-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SNCB Fusion Protein Ag0772 (1-134 aa encoded by BC002902)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDVFMKGLS MAKEGVVAAA EKTKQGVTEA AEKTKEGVLY VGSKTREGVV QGVASVAEKT KEQASHLGGA VFSGAGNIAA ATGLVKREEF PTDLKPEEVA QEAAEEPLIE PLMEPEGESY EDPPQEEYQE YEPEA (1-134 aa encoded by BC002902)
靶标信息
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-synuclein; Phosphoneuroprotein 14; PNP 14
基因别名: AI838531; betaSYN; SNCB
UniProt ID: (Human) Q16143, (Mouse) Q91ZZ3, (Rat) Q63754
Entrez Gene ID: (Human) 6620, (Mouse) 104069, (Rat) 113893
