The PA1-836 immunogen is a synthetic peptide corresponding to residues Q(139) E D Q F D L T V G I T D P E K I(155) of human SNX1. This peptide (Cat. # PEP-286) is available for use in neutralization and control experiments.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
蛋白别名: MGC8664; SNX1A; sorting nexin 1A; Sorting nexin-1