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Invitrogen
SOCS6 Polyclonal Antibody
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SOCS6 Antibody (PA5-97307) in IHC (P)
Immunohistochemistry analysis of SOCS6 in paraffin-embedded human mammary cancer. Samples were incubated with SOCS6 Polyclonal antibody (Product # PA5-97307) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-97307
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SOCS6 (NP_0042232)
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS ETTCQEQANS LKSSASHNGD LHLHLDEHVP; Positive Samples: A-549, Mouse heart, Mouse kidney
靶标信息
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CIS-4; cytokine inducible SH2-containing protein 4; cytokine inducible SH2-containing protein CIS4; Cytokine-inducible SH2 protein 4; SH2 domain containing SOCS box protein SOCS6; SOCS-4; SOCS-6; STAT induced STAT inhibitor-4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6
基因别名: 1500012M23Rik; 5830401B18Rik; AI447482; CIS-4; CIS4; Cish4; HSPC060; SOCS-4; SOCS-6; SOCS4; SOCS6; SSI4; STAI4; STATI4
UniProt ID: (Human) O14544, (Mouse) Q9JLY0
Entrez Gene ID: (Human) 9306, (Mouse) 54607
negative regulation of protein kinase activity
defense response
JAK-STAT cascade
proteasomal protein catabolic process
protein ubiquitination
cytokine-mediated signaling pathway
regulation of growth
negative regulation of JAK-STAT cascade
negative regulation of T cell activation
cellular glucose homeostasis
negative regulation of signal transduction
intracellular signal transduction
