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Invitrogen

SOD1 Polyclonal Antibody

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查看其他62个SOD1抗体

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SOD1 Polyclonal Antibody

产品信息

PA5-81939

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL
-

免疫组化（石蜡） (IHC (P))

1:1,000-1:2,500
-

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human SOD1. Recombinant protein control fragment (Product #RP-99374).
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

规格

10 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2789100

产品详细信息

Immunogen sequence: PVQGIINFEQ KESNGPVKVW GSIKGLTEGL HGFHVHEFGD NTAGCTSAGP HFNPLSRKHG GPKDEERHVG DLGNVTADKD GVADVSIEDS VISLSGDHCI IGRTLVVHEK ADDLGKGGNE ESTKTGNAGS RLACG

Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 81%.

靶标信息

SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: amyotrophic lateral sclerosis 1; Amyotrophic lateral sclerosis 1 (ALS1); Cu(2+)-Zn2+ superoxide dismutase; Cu, Zn superoxide dismutase (EC 1.15.1.1); Cu-Zn superoxide dismutase (EC 1.15.1.1); Cu-Zn superoxide dismutase (EC 1.15.11); Cu/Zn SOD; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HGNC:11179; hydrogen sulfide oxidase; indophenoloxidase A; Indophenoloxidase A (IPOA); indophenoloxidase A; soluble; cystolic; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; SOD, soluble; SOD1; superoxide dismutase; Superoxide Dismutase 1 (SOD1); superoxide dismutase 1, soluble; superoxide dismutase, cystolic; unnamed protein product

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基因别名: ALS; ALS1; B430204E11Rik; Cu/Zn-SOD; CuZnSOD; HEL-S-44; homodimer; hSod1; Ipo-1; Ipo1; IPOA; SOD; Sod-1; SODC; STAHP

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UniProt ID: (Human) P00441, (Mouse) P08228, (Rat) P07632

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Entrez Gene ID: (Human) 6647, (Mouse) 20655, (Rat) 24786

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功能
superoxide dismutase activity copper ion binding protein binding zinc ion binding enzyme binding protein phosphatase 2B binding small GTPase binding identical protein binding protein homodimerization activity metal ion binding chaperone binding
参与通路
response to reactive oxygen species response to superoxide ovarian follicle development positive regulation of cytokine production retina homeostasis response to amphetamine myeloid cell homeostasis glutathione metabolic process superoxide metabolic process cellular iron ion homeostasis response to oxidative stress spermatogenesis embryo implantation sensory perception of sound locomotory behavior anterograde axonal transport retrograde axonal transport regulation of blood pressure determination of adult lifespan response to heat response to xenobiotic stimulus gene expression transmission of nerve impulse neuronal action potential removal of superoxide radicals response to nutrient levels peripheral nervous system myelin maintenance positive regulation of superoxide anion generation response to carbon monoxide cellular response to oxidative stress cellular response to potassium ion regulation of multicellular organism growth response to hydrogen peroxide superoxide anion generation negative regulation of apoptotic process positive regulation of catalytic activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process response to ethanol response to copper ion muscle cell cellular homeostasis response to axon injury hydrogen peroxide biosynthetic process negative regulation of inflammatory response positive regulation of phagocytosis regulation of mitochondrial membrane potential heart contraction neurofilament cytoskeleton organization relaxation of vascular smooth muscle auditory receptor cell stereocilium organization cellular response to cadmium ion cellular response to ATP reactive oxygen species metabolic process response to antipsychotic drug action potential initiation positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway placenta development regulation of T cell differentiation in thymus positive regulation of apoptotic process regulation of GTPase activity regulation of organ growth thymus development
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