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This antibody is predicted to react with bovine, canine, human and rat based on sequence homology.
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 domain-containing receptor family, and the low density lipoprotein receptor family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
Protein Aliases: FLJ21930; FLJ39258; LDLR relative with 11 ligand-binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; mosaic protein LR11; SorLA; SorLA-1; Sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; Sorting protein-related receptor containing LDLR class A repeats
Gene Aliases: C11orf32; gp250; LR11; LRP9; SORL1; SORLA; SorLA-1
UniProt ID: (Human) Q92673
Entrez Gene ID: (Human) 6653