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Invitrogen
SOX1 Polyclonal Antibody
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SOX1 Antibody (PA5-23351) in WB
Western blot analysis of SOX1 in D3 cell lysate in the 1) absence and 2) presence of immunizing peptide. Samples were incubated in SOX1 polyclonal antibody (Product # PA5-23351) using a dilution of 1 µg/mL followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
产品信息
PA5-23351
产品规格
种属反应
Horse,
Human,
Marsupial,
Mouse,
Non-human primate,
Xenopus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 100-150 of human SOX1.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: sex determining region Y-box 1; sox1; SRY (Sex determining region Y)-box 1; SRY box 1; SRY-box containing gene 1; SRY-box containing protein; SRY-related HMG-box gene 1; Transcription factor SOX-1; XlSox1
基因别名: BB176347; Sox-1; SOX1; XELAEV_18015596mg; XlSox1; XSox1
UniProt ID: (Human) O00570, (Mouse) P53783, (Western clawed frog) A2TED3, (Xenopus) Q2PG84
Entrez Gene ID: (Human) 6656, (Mouse) 20664, (Western clawed frog) 779569, (Xenopus) 734174
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
HMG box transcription factor
neuron migration
lens morphogenesis in camera-type eye
chromatin organization
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
ventral spinal cord interneuron specification
forebrain neuron development
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
forebrain neuron differentiation
forebrain development
