Proteintech

SOX2 Polyclonal Antibody

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SOX2 Polyclonal Antibody

产品信息

20118-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
查看13篇已发表文章 13篇已发表文章

免疫组化 (IHC)

-
查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500
-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:50-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:500
查看3篇已发表文章 3篇已发表文章

流式细胞分析 (Flow)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

SOX2 Fusion Protein Ag13635 (1-317 aa encoded by BC013923)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.33 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody is a rabbit polyclonal antibody raised against an internal region of human SOX2. a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal differentiation. Sox2-expressing neural stem cells in the subgranular zone (SGZ), a well-known stem cell niche of the adult brain.

Immunogen sequence: MYNMMETEL KPPGPQQTSG GGGGNSTAAA AGGNQKNSPD RVKRPMNAFM VWSRGQRRKM AQENPKMHNS EISKRLGAEW KLLSETEKRP FIDEAKRLRA LHMKEHPDYK YRPRRKTKTL MKKDKYTLPG GLLAPGGNSM ASGVGVGAGL GAGVNQRMDS YAHMNGWSNG SYSMMQDQLG YPQHPGLNAH GAAQMQPMHR YDVSALQYNS MTSSQTYMNG SPTYSMSYSQ QGTPGMALGS MGSVVKSEAS SSPPVVTSSS HSRAPCQAGD LRDMISMYLP GAEVPEPAAP SRLHMSQHYQ SGPVPGTAIN GTLPLSHM (1-317 aa encoded by BC013923)

靶标信息

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box containing gene 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

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基因别名: ANOP3; lcc; MCOPS3; RGD1565646; Sox-2; SOX2; ysb

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UniProt ID: (Human) P48431, (Mouse) P48432

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Entrez Gene ID: (Human) 6657, (Rat) 499593, (Mouse) 20674

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功能
transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function chromatin binding transcription factor binding protein heterodimerization activity chromatin DNA binding HMG box transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation eye development endodermal cell fate specification chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest response to wounding regulation of gene expression glial cell fate commitment pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance cell fate specification positive regulation of neuroblast proliferation regulation of transcription from RNA polymerase II promoter sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis transcription, DNA-templated multicellular organism development
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