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Proteintech
SP100 Polyclonal Antibody
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产品信息
11377-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SP100 Fusion Protein Ag1939 (1-327 aa encoded by BC011562)
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAGGGGDLS TRRLNECISP VANEMNHLPA HSHDLQRMFT EDQGVDDRLL YDIVFKHFKR NKVEISNAIK KTFPFLEGLR DRDLITNKMF EDSQDSCRNL VPVQRVVYNV LSELEKTFNL PVLEALFSDV NMQEYPDLIH IYKGFENVIH DKLPLQESEE EEREERSGLQ LSLEQGTGEN SFRSLTWPPS GSPSHAGTTP PENGLSEHPC ETEQINAKRK DTTSDKDDSL GSQQTNEQCA QKAEPTESCE QIAVQVNNGD AGREMPCPLP CDEESPEAEL HNHGIQINSC SVRLVDIKKE KPFSNSKVEC QAQARTHHNQ ASDIIVIS (1-327 aa encoded by BC011562)
靶标信息
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp686E07254; FLJ00340; FLJ34579; Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; SP 100; SP100-HMG nuclear autoantigen; Speckled 100 kDa
基因别名: lysp100b; SP100
UniProt ID: (Human) P23497
Entrez Gene ID: (Human) 6672
negative regulation of transcription from RNA polymerase II promoter
telomere maintenance
transcription, DNA-templated
inflammatory response
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of endothelial cell migration
viral process
protein sumoylation
response to type I interferon
response to interferon-gamma
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of angiogenesis
positive regulation of transcription, DNA-templated
negative regulation of protein export from nucleus
negative regulation of cellular component movement
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of Fas signaling pathway
