Invitrogen

SP100 Polyclonal Antibody

产品信息

PA5-50076

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:3,000	-

产品规格
种属反应	Human
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthesized peptide derived from Internal of human SP100. 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20°C
RRID	AB_2635529

产品详细信息

The antibody detects endogenous levels of total SP100 protein.

靶标信息

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp686E07254; FLJ00340; FLJ34579; Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; SP 100; SP100-HMG nuclear autoantigen; Speckled 100 kDa

基因别名: lysp100b; SP100

UniProt ID: (Human) P23497

Entrez Gene ID: (Human) 6672

功能

negative regulation of transcription from RNA polymerase II promoter telomere maintenance transcription, DNA-templated inflammatory response DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator negative regulation of endothelial cell migration viral process protein sumoylation response to type I interferon response to interferon-gamma negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity regulation of angiogenesis positive regulation of transcription, DNA-templated negative regulation of protein export from nucleus negative regulation of cellular component movement interferon-gamma-mediated signaling pathway type I interferon signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of Fas signaling pathway

参与通路

DNA binding transcription coactivator activity transcription corepressor activity cytokine activity protein binding kinase binding protein domain specific binding protein homodimerization activity chromo shadow domain binding

SP100 Polyclonal Antibody

产品信息

PA5-50076

免疫印迹 (WB)

种属反应

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

性能保障

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