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Peptide sequence: LHVGKEKYSK RPTKKKTPRD YAEWDKFDVE KECLKIDEDY KEKTVIDKSH
Sequence homology: Dog: 85%; Human: 100%
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis secretory protein Li 268; HSD-3.8; Infertility-related sperm protein Spag-1; Sperm-associated antigen 1; tetratricopeptide repeat-containing protein; TPR-containing protein involved in spermatogenesis
基因别名: CILD28; CT140; HEL-S-268; HSD-3.8; SP75; SPAG1; TPIS
UniProt ID: (Human) Q07617
Entrez Gene ID: (Human) 6674