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SPARC Antibody (710030) in IHC (P)
Immunohistochemistry analysis of OSTEONECTIN showing staining in the cytoplasm of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperatu... View More
产品信息
710030
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
12HCLC
抗原
Protein corresponding to amino acids 18-303 of human Osteonectin
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532533
产品详细信息
This antibody is predicted to react with mouse based on sequence homology.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
SPARC gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basement membrane protein 40; Basement-membrane protein 40; BM-40; BM40; Cysteine rich protein; ON; Osteonectin; Secreted acidic cystein rich glycoprotein; Secreted protein acidic and rich in cysteine; Secreted protein acidic and rich in cysteine (SPARC); secreted protein, acidic, cysteine-rich (osteonectin); SPARC
基因别名: BM-40; OI17; ON; SPARC
UniProt ID: (Human) P09486
Entrez Gene ID: (Human) 6678
ossification
negative regulation of endothelial cell proliferation
platelet degranulation
receptor-mediated endocytosis
signal transduction
heart development
response to gravity
response to lead ion
positive regulation of endothelial cell migration
negative regulation of angiogenesis
regulation of cell morphogenesis
extracellular matrix organization
lung development
response to lipopolysaccharide
response to L-ascorbic acid
response to cytokine
wound healing
response to peptide hormone
response to ethanol
response to cadmium ion
inner ear development
response to glucocorticoid
response to cAMP
response to calcium ion
bone development
cellular response to growth factor stimulus
