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Invitrogen
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: APC-stimulated guanine nucleotide exchange factor 2; Asef2; Spermatogenesis-associated protein 13; spt13
基因别名: C79050; ESTM11; mFLJ00298; SPATA13; X83327
UniProt ID: (Mouse) Q5DU57
Entrez Gene ID: (Rat) 305938, (Mouse) 219140