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Proteintech
SPDEF Polyclonal Antibody
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产品信息
11467-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SPDEF Fusion Protein Ag2020 (1-335 aa encoded by BC021299)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGSASPGLS SVSPSHLLLP PDTVSRTGLE KAAAGAVGLE RRDWSPSPPA TPEQGLSAFY LSYFDMLYPE DSSWAAKAPG ASSREEPPEE PEQCPVIDSQ APAGSLDLVP GGLTLEEHSL EQVQSMVVGE VLKDIETACK LLNITADPMD WSPSNVQKWL LWTEHQYRLP PMGKAFQELA GKELCAMSEE QFRQRSPLGG DVLHAHLDIW KSAAWMKERT SPGAIHYCAS TSEESWTDSE VDSSCSGQPI HLWQFLKELL LKPHSYGRFI RWLNKEKGIF KIEDSAQVAR LWGIRKNRPA MNYDKLSRSI RQYYKKGIIR KPDISQRLVY QFVHPI (1-335 aa encoded by B C021299)
靶标信息
PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Prostate epithelium-specific Ets transcription factor; prostate specific ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; SAM pointed domain-containing Ets transcription factor
基因别名: bA375E1.3; PDEF; PSE; SPDEF
UniProt ID: (Human) O95238, (Mouse) Q9WTP3
Entrez Gene ID: (Human) 25803, (Mouse) 30051, (Rat) 689210
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
negative regulation of cell fate commitment
positive regulation of cell fate commitment
cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
lung goblet cell differentiation
intestinal epithelial cell development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
