应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
3-5 µg/mL | - |
产品规格 | |
---|---|
种属反应 |
Bovine, Dog, Horse, Human, Mouse, Non-human primate |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide (23 FYDLDSCKHSSYPDSEGA 40) of Spi-B protein. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Protein A |
保存液 |
PBS with 0.05% BSA |
内含物 |
0.05% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2541001 |
Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ets transcription factor Spi-B; Spi-1/PU.1 related; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B
基因别名: B42b-like; SPI-B; SPIB
UniProt ID: (Human) B4DUG6, (Mouse) O35906
Entrez Gene ID: (Bovine) 784460, (Dog) 100688036, (Horse) 102150831, (Human) 6689, (Mouse) 272382