Invitrogen

SPIB Polyclonal Antibody

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SPIB Antibody in Western Blot (WB) — Western blot analysis of SPIB using a polyclonal antibody (Product # PA5-23501).

产品信息

PA5-23501

应用	建议稀释比	已发表文章
免疫印迹 (WB)	3-5 µg/mL	-

产品规格
种属反应	Bovine, Dog, Horse, Human, Mouse, Non-human primate
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide (23 FYDLDSCKHSSYPDSEGA 40) of Spi-B protein.
偶联物	Unconjugated
形式	Liquid
浓度	0.5 mg/mL
纯化类型	Protein A
保存液	PBS with 0.05% BSA
内含物	0.05% sodium azide
保存条件	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2541001

靶标信息

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。