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Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
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蛋白别名: Ets transcription factor Spi-B; Spi-1/PU.1 related; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B
基因别名: B42b-like; SPI-B; SPIB
UniProt ID: (Human) B4DUG6, (Mouse) O35906
Entrez Gene ID: (Bovine) 784460, (Dog) 100688036, (Horse) 102150831, (Human) 6689, (Mouse) 272382
