Immunogen sequence: ENSAKKKLLR GGLAERLNGL QNRERSAISL WRHQCISYQK TLSGRKSGVL TVKILELHEE CAMQVAMCEQ LLGSPATSSS QSVAPR
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 74%.
Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.
蛋白别名: DNA repair-scaffolding protein; k0146; Scaffolding protein involved in DNA repair
基因别名: KIAA0146; SPIDR
UniProt ID: (Human) Q14159
Entrez Gene ID: (Human) 23514
分子生物学功能: DNA metabolism protein