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Invitrogen
SPPL2B Polyclonal Antibody
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产品信息
PA5-65229
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: YWAGSRDVKKR YMKHKRDDGP EKQEDEAVDV
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 90%.
靶标信息
SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IMP-4; Intramembrane protease 4; MGC111084; Presenilin homologous protein 4; Presenilin-like protein 1; PSH4; Signal peptide peptidase-like 2B; SPP-like 2B
基因别名: IMP-4; IMP4; KIAA1532; PSH4; PSL1; SPPL2B
UniProt ID: (Human) Q8TCT7
Entrez Gene ID: (Human) 56928
