Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-64897
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant Human SPPL3 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.2 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2664175 |
产品详细信息
Immunogen sequence: FNSNVMVKVAT QPADNPLDVL SRKLHLGPNV GRDVPRLSLP GKLVFPSSTG
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. SPPL3 is one of several presenilin homologues/SPP-like proteins (PSHs/SPPL) that have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: IMP-2; Intramembrane protease 2; Presenilin homologous protein 1; Presenilin-like protein 4; PSH1; Signal peptide peptidase-like 3; SPP-like 3
基因别名: IMP2; MDHV1887; PRO4332; PSH1; PSL4; SPPL3
UniProt ID: (Human) Q8TCT6
Entrez Gene ID: (Human) 121665
分子生物学功能:
aspartic protease
signal peptide processing
membrane protein ectodomain proteolysis
positive regulation of cytosolic calcium ion concentration
positive regulation of protein binding
membrane protein proteolysis
positive regulation of protein dephosphorylation
T cell receptor signaling pathway
positive regulation of NFAT protein import into nucleus
positive regulation of calcineurin-NFAT signaling cascade
