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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化 (IHC) |
1:200-1:500 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant protein corresponding to Human SPRY1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.2 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2647891 |
Immunogen sequence: PRTAPRQEKH ERTHEIIPIN VNNNYEHRHT SHLGHAVLPS NARGPILSRS TSTGSAASSG SNSSASSEQG LLGRSPP
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 74%.
Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1-4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing pathways leading to MAP kinase activation. Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts. A recent study shows that Sprouty-1 and -2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling; sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); Spry-1
基因别名: hSPRY1; SPRY1
UniProt ID: (Human) O43609
Entrez Gene ID: (Human) 10252
分子生物学功能:
scaffold/adaptor protein
