Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
SPRY2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
11383-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SPRY2 Fusion Protein Ag1918 (1-315 aa encoded by BC015745)
偶联物
形式
Liquid
浓度
0.43 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MEARAQSGN GSQPLLQTPR DGGRQRGEPD PRDALTQQVH VLSLDQIRAI RNTNEYTEGP TVVPRPGLKP APRPSTQHKH ERLHGLPEHR QPPRLQHSQV HSSARAPLSR SISTVSSGSR SSTRTSTSSS SSEQRLLGSS FSSGPVADGI IRVQPKSELK PGELKPLSKE DLGLHAYRCE DCGKCKCKEC TYPRPLPSDW ICDKQCLCSA QNVIDYGTCV CCVKGLFYHC SNDDEDNCAD NPCSCSQSHC CTRWSAMGVM SLFLPCLWCY LPAKGCLKLC QGCYDRVNRP GCRCKNSNTV CCKVPTVPPR NFEKPT (1-315 aa encoded by B C015745)
靶标信息
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: MGC23039; Protein sprouty homolog 2; sprouty 2; Spry-2
基因别名: hSPRY2; IGAN3; sprouty2; SPRY2
UniProt ID: (Human) O43597, (Mouse) Q9QXV8
Entrez Gene ID: (Human) 10253, (Mouse) 24064, (Rat) 306141
establishment of mitotic spindle orientation
sensory perception of sound
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of peptidyl-threonine phosphorylation
negative regulation of cell projection organization
positive regulation of peptidyl-serine phosphorylation
negative regulation of GTPase activity
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
inner ear morphogenesis
negative regulation of apoptotic process
negative regulation of MAP kinase activity
cell fate commitment
regulation of cell differentiation
negative regulation of Ras protein signal transduction
negative regulation of neurotrophin TRK receptor signaling pathway
positive regulation of protein kinase B signaling
lung growth
bud elongation involved in lung branching
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
multicellular organism development
regulation of signal transduction
lung development
branching morphogenesis of an epithelial tube
lung morphogenesis
respiratory system development
