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SPTBN2 Monoclonal Antibody (4D9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00006712-M06
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG3, kappa
分类
Monoclonal
类型
Antibody
克隆号
4D9
抗原
SPTBN2 (NP_008877, 643 a.a. approximately 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: LWRFLWEVGE AEAWVREQQH LLASADTGRD LTGALRLLNK HTALRGEMSG RLGPLKLTLE QGQQLVAEGH PGASQASA
靶标信息
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta-III spectrin; cytoskeletal protein; glutamate transporter EAAT4-associated protein 41; membrane associated cytoskeletal protein; Spectrin Beta; spectrin beta chain, brain 2; spectrin beta III sigma 2; spectrin, non-erythroid beta chain 2; spinocerebellar ataxia 5 protein
基因别名: GTRAP41; SCA5; SCAR14
UniProt ID: (Human) O15020
Entrez Gene ID: (Human) 6712
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