Abnova

SRD5A1 Polyclonal Antibody, MaxPab™

Name: SRD5A1 Polyclonal Antibody, MaxPab\u2122
Brand: Abnova
SKU: H00006715-D01P

查看其他7个SRD5A1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

图: 1 / 1

SRD5A1 Antibody (H00006715-D01P) in WB

Western Blot analysis of SRD5A1 expression in transfected 293T cell line (H00006715-T03) by SRD5A1 MaxPab polyclonal antibody.

Lane 1: SRD5A1 transfected lysate(29.50 KDa).
Lane 2: Non-transfected lysate.

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Immunogen image

Immunogen Image SRD5A1 Polyclonal Antibody, MaxPab™

产品信息

H00006715-D01P

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

SRD5A1 (NP_001038.1, 1 a.a. approximately 259 a.a) full-length human protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF RKIIIPFLF

靶标信息

Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; S5AR 1; SR type 1; Steroid 5-alpha-reductase 1; steroid 5-alpha-reductase type I; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

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基因别名: S5AR 1; SRD5A1

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UniProt ID: (Human) P18405

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Entrez Gene ID: (Human) 6715

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功能

3-oxo-5-alpha-steroid 4-dehydrogenase activity electron carrier activity amide binding cholestenone 5-alpha-reductase activity NADPH binding dehydrogenase

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