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Proteintech
SREBF1 Polyclonal Antibody
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产品信息
14088-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Bovine,
Chicken,
Goat,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SREBF1 Fusion Protein Ag5219 (1-332 aa encoded by BC063281)
偶联物
形式
Liquid
浓度
0.54 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody can recognize the 125 kDa precursor form and the 68 kDa mature form of human SREBF1.
Immunogen sequence: MDEPPFSEA ALEQALGEPC DLDAALLTDI EGEVGAGRGR ANGLDAPRAG ADRGAMDCTF EDMLQLINNQ DSDFPGLFDP PYAGSGAGGT DPASPDTSSP GSLSPPPATL SSSLEAFLSG PQAAPSPLSP PQPAPTPLKM YPSMPAFSPG PGIKEESVPL SILQTPTPQP LPGALLPQSF PAPAPPQFSS TPVLGYPSPP GGFSTGSPPG NTQQPLPGLP LASPPGVPPV SLHTQVQSVV PQQLLTVTAA PTAAPVTTTV TSQIQQVPVL LQPHFIKADS LLLTAMKTDG ATVKAAGLSP LVSGTTVQTG PLPTLVSGGT ILATVPLVVD AEK (1-332 aa encoded by BC063281)
靶标信息
Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bHLHd1; Class D basic helix-loop-helix protein 1; nt-SREBP1; SREBP-1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1
基因别名: BHLHD1; SREBF1; SREBP-1c; SREBP1; SREBP1a
UniProt ID: (Human) P36956
Entrez Gene ID: (Human) 6720
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
protein complex binding
sterol response element binding
protein dimerization activity
negative regulation of transcription from RNA polymerase II promoter
regulation of heart rate by chemical signal
regulation of transcription from RNA polymerase II promoter
lipid metabolic process
aging
circadian rhythm
cholesterol metabolic process
insulin receptor signaling pathway
lipid biosynthetic process
cellular response to starvation
response to glucose
positive regulation of triglyceride biosynthetic process
regulation of fatty acid metabolic process
lung development
positive regulation of histone deacetylation
regulation of protein stability
response to food
response to retinoic acid
response to progesterone
response to glucagon
response to drug
mRNA transcription from RNA polymerase II promoter
fat cell differentiation
positive regulation of cholesterol biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
response to cAMP
cellular response to fatty acid
regulation of mitophagy
regulation of protein targeting to mitochondrion
