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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SREBP1 Antibodies

          Invitrogen

          SREBP1 Monoclonal Antibody (2A4)

          3个已发表图片
          24 篇参考文献
          查看其他17个SREBP1抗体
          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite SREBP1 Monoclonal Antibody (2A4)

          • 抗体检测数据 (1)
          • 已发表图片 (3)
          SREBP1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          SREBP1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 4

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          SREBP1 Antibody (MA5-16124) in WB

          Western blot analysis of SREBP1 using a monoclonal antibody (Product # MA5-16124). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          SREBP1 Antibody in Western Blot (WB)
          SREBP1 Antibody in Western Blot (WB)
          SREBP1 Antibody in Western Blot (WB)
          SREBP1 Antibody in Western Blot (WB)

          产品信息

          MA5-16124

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1-2 µg/mL
          查看22篇已发表文章 22篇已发表文章

          免疫组化 (IHC)

          -
          查看1篇已发表文章 1篇已发表文章

          流式细胞分析 (Flow)

          -
          查看1篇已发表文章 1篇已发表文章
          产品规格

          种属反应

          Dog, Chicken, Hamster, Human, Mouse, Rat

          已发表种属

          Avian, Human, Mouse, Rat

          宿主/亚型

          Mouse / IgG1, kappa

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          2A4

          抗原

          6 His-tag fusion protein of SREBP1 corresponding to amino acids 301-407

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Protein G

          保存液

          PBS

          内含物

          0.05% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_11152118

          产品详细信息

          In Western blot, a band can be seen at 125 kDa (precursor) and additional bands may be seen at 60-70 kDa (cleaved).

          Suggested positive control: IMR 5 and HeLa cells..

          靶标信息

          Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: ADD1; Adipocyte determination- and differentiation-dependent factor 1; bHLHd1; Class D basic helix-loop-helix protein 1; nt-SREBP1; SREBP-1; SREBP1; sterol regulatory element binding protein 1; sterol regulatory element binding protein-1; sterol regulatory element binding-protein 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1

          查看更多 收起

          基因别名: ADD-1; ADD1; BHLHD1; D630008H06; I79_010155; SREBF1; SREBP-1; SREBP-1a; SREBP-1c; SREBP1; SREBP1a; SREBP1c

          查看更多 收起

          UniProt ID: (Human) P36956, (Rat) P56720, (Chinese hamster) Q60416, (Mouse) Q9WTN3

          查看更多 收起

          Entrez Gene ID: (Human) 6720, (Chicken) 373915, (Dog) 403475, (Rat) 78968, (Chinese hamster) 100689018, (Mouse) 20787

          查看更多 收起

          功能
          RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding protein complex binding sterol response element binding protein dimerization activity sequence-specific DNA binding transcription regulatory region DNA binding
          参与通路
          negative regulation of transcription from RNA polymerase II promoter regulation of heart rate by chemical signal regulation of transcription from RNA polymerase II promoter lipid metabolic process aging circadian rhythm cholesterol metabolic process insulin receptor signaling pathway lipid biosynthetic process cellular response to starvation response to glucose positive regulation of triglyceride biosynthetic process regulation of fatty acid metabolic process lung development positive regulation of histone deacetylation regulation of protein stability response to food response to retinoic acid response to progesterone response to glucagon response to drug mRNA transcription from RNA polymerase II promoter fat cell differentiation positive regulation of cholesterol biosynthetic process positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion response to cAMP cellular response to fatty acid regulation of mitophagy regulation of protein targeting to mitochondrion transcription, DNA-templated regulation of transcription, DNA-templated response to organic cyclic compound response to insulin cellular response to insulin stimulus response to lipid response to peptide hormone positive regulation of transcription, DNA-templated regulation of insulin secretion response to fatty acid transcription from RNA polymerase II promoter steroid metabolic process positive regulation of fatty acid biosynthetic process
          It has to be done as per old AB suggested Products section.
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          只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符,您即可享受免费退换货服务。*

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