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Proteintech
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This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SRRM1.
Immunogen sequence: MDAGFFRGT SAEQDNRFSN KQKKLLKQLK FAECLEKKVD MSKVNLEVIK PWITKRVTEI LGFEDDVVIE FIFNQLEVKN PDSKMMQINL TGFLNGKNAR EFMGELWPLL LSAQENIAGI PSAFLELKKE EIKQRQIEQE KLASMKKQDE DKDKRDKEEK ESSREKRERS HSPRRRKSRS PSPRRRSSPV RRERKRSHSR SPRHRTKSRS PSPAPEKKEK TPELPEPSVK VKEPSVQEAT STSDILKVPK PEPIPEPKEP SPEKNSKKEK EKEKTQPRSR SRSKSRSRTR SRSPSHTRPR RRHRSRSRSY SPRRRPSPRR RPSPRRRTPP RRMPPPPRHR RSRSPVRRRR R (1-350 aa encoded by BC036187)
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Plenty-of-prolines 101; plenty-of-prolines-101; Ser/Arg-related nuclear matrix protein; serine/arginine repetitive matrix 1; Serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kDa; SRm160
基因别名: 160-KD; AA407769; POP101; SRM160; SRRM1
UniProt ID: (Human) Q8IYB3, (Mouse) Q52KI8
Entrez Gene ID: (Human) 10250, (Mouse) 51796, (Rat) 313620